CASE PRACTICE

Put knowledge into practice

32 original case and concept questions. Read the explanation after each answer and revisit the relevant chapter.

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1. Calculate conduction velocity

Stimulation sites are 240 mm apart. Distal onset latency is 3.2 ms and proximal onset latency is 8.0 ms. What is the segmental motor velocity?

  1. 30 m/s
  2. 50 m/s
  3. 75 m/s
  4. 5,000 m/s
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Answer: 50 m/s

240 ÷ (8.0 − 3.2) = 50 m/s. Use the latency difference; mm/ms already has the numerical value of m/s.

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2. Choose the right cursor

Which latencies are compared when calculating motor conduction velocity between two stimulation sites?

  1. CMAP peak latencies
  2. Mean F-wave latencies
  3. CMAP onset latencies
  4. Minimum H-reflex latencies
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Answer: CMAP onset latencies

Segmental motor velocity uses proximal minus distal CMAP onset latency, removing the shared distal pathway time. Peak position is also influenced by dispersion.

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3. An unexpectedly cold hand

Hand skin temperature is 28°C and several sensory latencies are prolonged. What is the best next step?

  1. Diagnose CIDP immediately
  2. Apply a percentage correction and finish
  3. Keep only the most normal nerve
  4. Warm the limb, document temperature and repeat measurements
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Answer: Warm the limb, document temperature and repeat measurements

Cold may prolong latency and slow velocity. Restore method-matched acquisition conditions before distinguishing technical effects from disease.

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4. Nocturnal hand paresthesia

Radial digits become numb at night. After warming, matched same-hand comparisons show relative median slowing. Which site is best supported?

  1. Median nerve at the wrist
  2. Ulnar nerve at the elbow
  3. Common fibular nerve at the fibular head
  4. Isolated anterior interosseous nerve
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Answer: Median nerve at the wrist

Focal median delay relative to neighboring nerves supports wrist localization. The AIN has no cutaneous supply. Clinical findings and the remaining study must still agree.

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5. An incomplete OK sign

Thumb IP and index DIP flexion are weak without cutaneous sensory loss. Which branch best fits?

  1. Superficial radial
  2. Anterior interosseous
  3. Dorsal ulnar cutaneous
  4. Suprascapular
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Answer: Anterior interosseous

FPL and index FDP are AIN muscles, and the AIN has no skin territory. Assess PQ and consider tendon injury or a more proximal fascicular lesion.

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6. Palmar symptoms with dorsal sparing

Hand intrinsic weakness and ulnar palmar numbness occur with a preserved DUC response. Which site deserves particular assessment?

  1. Isolated C5 root
  2. Femoral nerve
  3. Guyon canal
  4. Lateral antebrachial cutaneous nerve
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Answer: Guyon canal

DUC leaves proximal to the wrist and is commonly spared in Guyon canal disease. This is not diagnostic alone; assess the across-elbow segment and other muscles.

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7. Finger extension weakness

Finger extension is weak, wrist extension is preserved with radial deviation, and radial dorsal hand sensation is normal. Which branch best fits?

  1. PIN
  2. DUC
  3. MABC
  4. Saphenous nerve
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Answer: PIN

The PIN supplies most finger extensors and has no cutaneous supply. ECRL branches more proximally, allowing wrist extension with radial deviation. Compare proximal radial and C7–C8 muscles.

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8. Add one comparison muscle

To distinguish common fibular neuropathy from an L5 root lesion, which muscle gives L5 information outside the common fibular nerve?

  1. EDB
  2. Tibialis anterior
  3. Extensor hallucis longus
  4. Tibialis posterior
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Answer: Tibialis posterior

Tibialis posterior has tibial supply and L5 contribution. EDB, TA and EHL are deep fibular muscles. TP and TFL add cross-nerve information.

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9. The fibular division above the knee

Which muscle helps distinguish a sciatic fibular-division lesion from a fibular-head lesion?

  1. FDI
  2. Biceps femoris, short head
  3. EDB
  4. Abductor hallucis
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Answer: Biceps femoris, short head

The short head of biceps femoris receives fibular-division supply above the knee. Abnormality adds proximal information but still needs comparison with other muscles and root hypotheses.

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10. Knee extension and hip adduction

Knee extension is weak and the knee reflex is reduced, while hip adduction is preserved. Which mononeuropathy best fits?

  1. Obturator
  2. Superficial fibular
  3. Femoral
  4. Inferior gluteal
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Answer: Femoral

Quadriceps has femoral supply; hip adduction is mainly obturator. Saphenous SNAPs, adductors and paraspinals help compare lumbar plexus and L2–L4 lesions.

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11. Burning over the lateral thigh

Anterolateral thigh burning and numbness occur with normal strength and knee reflexes. Which nerve best matches?

  1. Lateral femoral cutaneous
  2. The entire femoral nerve
  3. Tibial
  4. Superior gluteal
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Answer: Lateral femoral cutaneous

The LFCN is sensory, and its dysfunction may cause meralgia paresthetica. Weakness or reflex abnormalities require a broader localization.

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12. Why SNAPs may be preserved

Why are distal SNAPs often preserved in a typical preganglionic root lesion?

  1. SNAPs are unaffected by all disease
  2. Root lesions never cause sensory symptoms
  3. Roots contain motor fibers only
  4. The lesion is usually proximal to the dorsal root ganglion
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Answer: The lesion is usually proximal to the dorsal root ganglion

Distal sensory axons and their ganglion cell bodies are relatively preserved in typical preganglionic disease. Exceptions and coexisting conditions prevent this clue from being diagnostic alone.

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13. Sensory abnormalities across nerves

Corresponding SNAPs are reduced and abnormal muscles span terminal nerves within a plexus distribution. Which pattern is more plausible?

  1. An isolated spinal cord lesion is certain
  2. A postganglionic plexus lesion
  3. Only myopathy is possible
  4. A normal study
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Answer: A postganglionic plexus lesion

Plexus disease may affect both corresponding SNAPs and muscles across terminal nerves. Exclude generalized neuropathy, multiple local nerve injuries and mixed root/plexus disease.

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14. One abnormal paraspinal site

Only one paraspinal site has spontaneous activity; sampled limb muscles are normal. What is the most appropriate interpretation?

  1. A severe single-root lesion is precisely proven
  2. Plexopathy is confirmed
  3. Consider nonspecific changes and sampling limitations
  4. This establishes ALS
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Answer: Consider nonspecific changes and sampling limitations

Isolated paraspinal abnormalities can be influenced by age or prior surgery. Interpret with limb findings and the clinical picture rather than assigning a precise root or disease alone.

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15. What fibrillations tell you

What is the best interpretation of fibrillation potentials and positive sharp waves?

  1. Muscle-fiber membrane instability; assess distribution and cause
  2. Always ALS
  3. Always compressive radiculopathy
  4. Always an injury exactly three weeks old
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Answer: Muscle-fiber membrane instability; assess distribution and cause

They occur with denervation and some myopathies, and are not specific to one disease or an exact injury date.

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16. An isolated fasciculation

Fasciculations are observed without progressive weakness or other neurogenic evidence. What should you conclude?

  1. ALS is already established
  2. Myositis is certain
  3. Complete normality is proven
  4. Clinical integration is needed; this alone does not diagnose ALS
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Answer: Clinical integration is needed; this alone does not diagnose ALS

Fasciculation is a discharge phenomenon occurring in benign and pathological settings. ALS assessment requires progression, distribution, neuronal evidence and exclusion of alternatives.

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17. More units at low force

Many short, small MUAPs appear with slight effort. Which pattern is most consistent?

  1. Typical reduced recruitment
  2. Myopathic early recruitment
  3. Pure sensory neuropathy
  4. Prolonged F waves
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Answer: Myopathic early recruitment

When each unit contains fewer effective fibers, more units are recruited for the same force. Interpret morphology with recruitment; severe or chronic myopathy may look mixed.

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18. Pain-limited effort

A patient is in pain, with a few units firing slowly and inconsistently. What should you consider first?

  1. Automatically label severe axonal loss
  2. Myotonia is certain
  3. Poor activation and participation limits
  4. Conduction block is proven
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Answer: Poor activation and participation limits

Poor activation differs from true reduced recruitment. Document pain and effort limitations rather than overcalling motor-unit loss.

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19. The day after an injury

A distal CMAP is still present one day after trauma. Does this exclude axonal injury?

  1. No; distal degeneration takes time
  2. Yes; every injury immediately abolishes the response
  3. It precisely predicts full recovery
  4. A normal SNAP excludes all injury
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Answer: No; distal degeneration takes time

Distal responses can persist before degeneration. Recruitment and other observations may still be useful. Decide follow-up from the clinical question rather than overinterpreting an early study.

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20. A smaller proximal CMAP

The proximal CMAP has lower amplitude and longer duration. What is the best next step?

  1. Immediately call complete block
  2. Ignore area and assess amplitude alone
  3. Diagnose ALS
  4. Check stimulation, area, dispersion and applicable criteria
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Answer: Check stimulation, area, dispersion and applicable criteria

Dispersion and phase cancellation may reduce amplitude; inadequate stimulation is also common. Assess the whole waveform and disease-specific criteria before supporting block.

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21. An unexpected ulnar amplitude gap

Ulnar proximal/distal CMAPs differ atypically, and median stimulation also activates the relevant hand muscle. What should you consider?

  1. Every discrepancy is pathological block
  2. Martin–Gruber communication
  3. Pure small-fiber disease
  4. Facial neuropathy
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Answer: Martin–Gruber communication

Forearm median-to-ulnar motor communication can alter CMAP distribution. Confirm systematically with consistent recording rather than diagnosing block from amplitude loss alone.

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22. The origin of an F wave

Which best describes an F wave?

  1. A typical Ia sensory reflex
  2. A purely mechanical muscle reflex
  3. A late response from backfiring of some motor neurons
  4. A sensory peak latency
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Answer: A late response from backfiring of some motor neurons

F waves arise from backfiring of a subset of motor neurons after stimulation. H reflexes include Ia input. An F-wave abnormality alone cannot precisely identify a root.

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23. Calculate decrement

The first RNS response is 10 mV and the fourth is 8.5 mV. What is the decline relative to the first?

  1. 15%
  2. 85%
  3. 1.5%
  4. 17.6%
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Answer: 15%

(10 − 8.5) ÷ 10 × 100 = 15%. The baseline is the denominator. Clinical meaning also requires reproducibility, technique and appropriate limits.

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24. Is jitter disease-specific?

Is increased jitter found only in myasthenia gravis?

  1. Yes, any increase confirms MG
  2. Yes, and it identifies the antibody
  3. Any increase requires stopping medication
  4. No; reinnervation and other conditions may increase it
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Answer: No; reinnervation and other conditions may increase it

Jitter is sensitive to transmission abnormality but is not specific to one cause. Interpret alongside routine EMG and clinical context.

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25. Burning pain with normal NCS

Burning feet and altered pain/temperature sensation occur with normal routine NCS. Which statement is correct?

  1. The symptoms cannot be neurological
  2. Small-fiber disease and other causes remain possible
  3. All neuromuscular diseases are excluded
  4. Small-fiber neuropathy is automatically confirmed
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Answer: Small-fiber disease and other causes remain possible

Routine NCS predominantly tests larger myelinated fibers. It does not exclude small-fiber disease, but symptoms plus normal NCS do not automatically establish that diagnosis either.

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26. One mildly slow nerve

One common compression segment is mildly slow and other evidence is insufficient. Can this diagnose CIDP?

  1. Yes; any slowing means CIDP
  2. Yes, if the hand is numb
  3. No; the full clinical and multinerve criteria are needed
  4. It excludes all local compression
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Answer: No; the full clinical and multinerve criteria are needed

CIDP requires time course, phenotype and the complete electrophysiological framework. Exclude cold, entrapment, very low CMAPs and other confounders.

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27. Acute progressive weakness

Rapid limb weakness and swallowing difficulty occur with nondiagnostic early NCS. What matters most?

  1. Continue urgent clinical assessment; early testing cannot exclude GBS
  2. Wait for every waveform to become typical
  3. A normal SNAP is enough to discharge the patient
  4. Arrange self-study only
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Answer: Continue urgent clinical assessment; early testing cannot exclude GBS

Respiratory, bulbar and autonomic risks need immediate assessment. Early EDX may be atypical and must not delay necessary care.

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28. A waxing and waning discharge

Repetitive single-muscle-fiber activity waxes and wanes in frequency and amplitude. Which pattern fits?

  1. F wave
  2. H reflex
  3. Normal SNAP
  4. Myotonic discharge
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Answer: Myotonic discharge

Myotonic discharges commonly wax and wane. Distinguish them from fixed repetitive CRDs and motor-unit-origin neuromyotonic discharges.

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29. A patient taking anticoagulants

How should a learner respond when a person scheduled for testing takes anticoagulants?

  1. Independently stop treatment for a week
  2. Have the appropriate clinical team assess risk and the study plan
  3. Prohibit all NCS automatically
  4. Ignore medication history
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Answer: Have the appropriate clinical team assess risk and the study plan

Bleeding and thrombotic risks must be balanced by the clinical team. A learning website cannot replace individualized medication or deep-muscle sampling decisions.

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30. Sensory versus mixed references

Can a plantar mixed-nerve amplitude limit be applied directly to another pure sensory technique?

  1. Yes, if the nerve name matches
  2. Yes, if the age matches
  3. No; match the stimulation, recording and parameter definitions
  4. Simply convert it to mV
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Answer: No; match the stimulation, recording and parameter definitions

Distance, recording method and amplitude definition determine whether reference data apply. Different techniques cannot be interchanged directly.

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31. The blink reflex pathway

What are the main input and output nerves of the conventional blink reflex?

  1. V1 input, VII output
  2. VII input, XI output
  3. II input, III output
  4. Phrenic input, ulnar output
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Answer: V1 input, VII output

The blink reflex integrates ophthalmic trigeminal input, brainstem circuits and facial output. The pupillary reflex is a different circuit.

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32. Limits of a negative report

Only routine large-fiber NCS was performed, without needle EMG. Which conclusion is appropriate?

  1. All myopathy and root disease are excluded
  2. All small-fiber disease is excluded
  3. All weakness is nonorganic
  4. Describe the tested responses and state the needle and small-fiber limitations
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Answer: Describe the tested responses and state the needle and small-fiber limitations

Conclusions must match the scope of testing. Without needle or specialized small-fiber assessment, a report cannot claim a complete exclusion of those conditions.

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